High Prevalence of Weight Gain in Childhood Brain Tumor Survivors and Its Association With Hypothalamic-Pituitary Dysfunction

PURPOSE Childhood brain tumor survivors (CBTS) are at risk for developing obesity, which negatively influences cardiometabolic health. The prevalence of obesity in CBTS may have been overestimated previous cohorts because inclusion children with craniopharyngioma. On the contrary, degree weight gain underestimated exclusion who experienced gain, but were neither overweight nor obese. Weight be an indicator underlying hypothalamic-pituitary (HP) dysfunction. We aimed to study and factors significant overweight, or its association HP dysfunction a national cohort noncraniopharyngioma nonpituitary CBTS. METHODS Prevalence (body mass index [BMI] change ? +2.0 standard deviation score [SDS]), follow-up, studied nationwide CBTS, diagnosed 10-year period (2002-2012), excluding all craniopharyngioma pituitary tumors. RESULTS Of 661 median age follow-up 7.3 years, 33.1% had obesity. between 4 20 years age, 28.7% obese, compared 13.2% general population age. BMI SDS diagnosis, diagnosis low-grade glioma, diabetes insipidus, central precocious puberty associated was higher obese CTBS normal-weight CONCLUSION Overweight, prevalent An increase during reflection dysfunction, necessitating more intense endocrine surveillance.